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. 2023 Sep 25;2(8):100622. doi: 10.1016/j.jacadv.2023.100622

Figure 1.

Figure 1

Pharmacologic Effects of Nonvasodilating Beta-Adrenergic Blockers on the Pathomechanisms of Obstructive Hypertrophic Cardiomyopathy

This drug class modulates the sympathetic tone leading to the following effects: 1) decrease in heart rate that causes prolongation of the diastolic phase, ultimately mitigating the obstructive effects on the LVOT; and 2) decrease in inotropy causing a decrease in myocardial oxygen demand and LVOT obstruction, both ultimately leading to the decrease of patient-felt symptoms. LVOT = left ventricular outflow tract.