Table 2.
Echocardiography and Right Heart Catheterization Measurements in Patients With Heart Failure With Preserved Ejection Fraction
| Women (n = 25) | Men (n = 9) | P Value | |
|---|---|---|---|
| Echocardiography | |||
| LAVI (mL/m2) | 41.7 (34.9 to 52.0) | 49.7 (40.3 to 63.0) | 0.263 |
| E/e’ rest | 12.7 (10.3 to 14.1) | 10.8 (8.6 to 12.6) | 0.086 |
| E/e’ stress | 14.9 (11.4 to 16.9) | 10.9 (9.6 to 14.1) | 0.094 |
| PAPsys (mm Hg) | 27.2 (23.4 to 31.1) | 33.0 (22.6 to 39.1) | 0.263 |
| LV-GLS rest (%) | −15.3 (−17.4 to −11.9) | −11.6 (−14.8 to −9.1) | 0.110 |
| LV-GLS stress (%) | −13.9 (−15.8 to −12.4) | −15.9 (−17.1 to −9.3) | 0.685 |
| LV-GLS reserve (%) | 0.9 (−3.5 to −3.9) | −1.5 (−4.6 to 2.8) | 0.570 |
| LA strain rest (%) | 23.2 (12.7 to 30.9) | 20.3 (7.7 to 23.3) | 0.381 |
| LA strain stress (%) | 20.7 (13.3 to 24.5) | 21.4 (9.6 to 31.6) | 0.808 |
| Right heart catheterization | |||
| Heartrate rest (beats/min) | 73 (65 to 78) | 70 (58 to 77) | 0.514 |
| Heartrate stress (beats/min) | 108 (97 to 110) | 102 (96 to 113) | 0.759 |
| Blood pressure rest (mm Hg) | 148/81 (134/75 to 156/90) | 152/96 (140/76 to 168/104) | 0.414 |
| Blood pressure stress (mm Hg) | 173/94 (150/82 to 199/101) | 196/104 (157/92 to 207/126) | 0.409 |
| Maximum workload (W) | 40 (27 to 55) | 75 (60 to 82) | <0.001 |
| PCWP rest (mm Hg) | 13.0 (10.5 to 18.5) | 15.0 (11.0 to 17.5) | 0.818 |
| PCWP/CO rest (mm Hg·min/mL) | 2.7 (1.8 to 3.7) | 1.9 (1.4 to 2.5) | 0.120 |
| PCWP stress (mm Hg) | 27.0 (26.0 to 31.0) | 26.0 (24.5 to 30.0) | 0.280 |
| PCWP/CO stress (mm Hg·min/mL) | 2.1 (2.7 to 4.2) | 1.9 (1.7 to 2.4) | <0.001 |
| PCWP/workload (mm Hg/W) | 0.7 (0.5 to 1.1) | 0.3 (0.3 to 0.4) | <0.001 |
| PA pressure rest (mm Hg) | 21.0 (20.0 to 26.5) | 26.0 (19.0 to 30.0) | 0.730 |
| PA pressure stress (mm Hg) | 43.0 (39.0 to 52.0) | 47.0 (38.0 to 53.0) | 0.818 |
| CO rest (mL/min) | 5.2 (4.5 to 5.9) | 7.2 (6.2 to 8.3) | <0.001 |
| CI rest (L/m2 BSA) | 2.7 (2.4 to 3.0) | 3.1 (2.9 to 3.8) | 0.022 |
| CO stress (mL/min) | 8.7 (6.6 to 10.3) | 13.0 (9.9 to 15.0) | 0.002 |
| CI stress (L/m2 BSA) | 4.9 (3.6 to 5.3) | 6.2 (4.7 to 6.9) | 0.015 |
| CI reserve (L/m2 BSA) | 1.9 (1.3 to 2.4); 67 ± 36 | 2.8 (1.7 to 3.2); 81 ± 49 | 0.066 |
| PVR rest (WU) | 1.7 (±1.4 to 2.4) | 1.2 (1.1 to 1.5) | 0.033 |
| PVR stress (WU) | 1.6 (1.3 to 2.7) | 1.4 (1.0 to 1.6) | 0.318 |
| PVR difference (WU) | −0.1 (−0.4 to 0.1) | 0.1 (−0.2 to 0.3) | 0.514 |
| Arterial elastance rest (mm Hg/mL) | 2.1 (1.6 to 2.6) | 1.3 (1.1 to 1.7) | 0.004 |
| Arterial elastance stress (mm Hg/mL) | 1.9 (1.6 to 2.4) | 1.4 (1.1 to 1.7) | 0.015 |
Values are median (IQR) (and were compared using the Mann-Whitney U test) or mean ± SD. Echocardiographic and right heart catheterization measurements in patients with HFpEF as defined by right heart catheterization. Data are presented according to patients’ sex. Bold values indicate statistical significance below 0.05.
BSA = body surface area; CO = cardiac output; CI = cardiac index; E = passive mitral inflow; e’ = septal and lateral mitral annulus velocity; GLS = global longitudinal strain; LA = left atrium; LAVI = left atrial volume index; LV/RV = left/right ventricle; PA = pulmonary artery; PAPsys = pulmonary artery systolic pressure; PCWP = pulmonary capillary wedge pressure; PVR = pulmonary vascular resistance.