Table 5.
Differences in Cardiac Magnetic Resonance Imaging Parameters in Patients With Noncardiac Dyspnea Compared to Patients With Heart Failure With Preserved Ejection Fraction
| Noncardiac Dyspnea |
HFpEF |
P Value |
||||||
|---|---|---|---|---|---|---|---|---|
| Women (n = 19) | Men (n = 15) | P Value | Women (n = 25) | Men (n = 9) | P Value | NCD vs HFpEF (Women) | NCD vs HFpEF (Men) | |
| Right ventricle | ||||||||
| Flow: stroke volume rest (mL/m2 BSA) | 36.7 (34.4 to 44.9) | 50.1 (34.6 to 56.1) | 0.027 | 39.2 (31.4 to 45.7) | 50.3 (43.9 to 57.3) | 0.004 | 0.883 | 0.861 |
| Flow: stroke volume stress (mL/m2 BSA) | 42.1 (38.2 to 49.6) | 48.1 (41.3 to 56.3) | 0.096 | 38.1 (35.6 to 49.3) | 50.4 (48.6 to 58.8) | 0.011 | 0.211 | 0.558 |
| Left atrium | ||||||||
| ΔLA EF (%) | 4.4 (2.1 to 7.5) | 4.2 (1.7 to 11.7) | 0.706 | −2.7 (−7.5 to 0.8) | 2.5 (−1.5 to 6.4) | 0.020 | <0.001 | 0.447 |
| LA filling reserve (mL/m2 BSA) | 3.3 (2.1 to 4.4) | 4.0 (1.8 to 5.4) | 0.758 | −0.4 (−1.9 to 1.6) | 2.1 (5.6 to 0.7) | 0.030 | <0.001 | 0.447 |
| Left ventricle | ||||||||
| LV filling rest (mL/m2 BSA) | 28.7 (23.7 to 35.0) | 33.4 (27.5 to 38.2) | 0.157 | 29.1 (24.7 to 34.2) | 34.5 (26.4 to 42.9) | 0.107 | 0.840 | 0.681 |
| LV filling stress (mL/m2 BSA) | 38.4 (32.7 to 44.1) | 43.2 (33.8 to 49.6) | 0.120 | 35.5 (30.7 to 40.3) | 48.0 (34.9 to 56.8) | 0.017 | 0.201 | 0.325 |
| LV filling reserve (mL/m2 BSA) | 9.0 (6.6 to 14.6) | 9.0 (5.1 to 15.9) | 0.973 | 5.3 (3.4 to 12.2) | 10.8 (7.4 to 18.3) | 0.061 | 0.126 | 0.428 |
Values are median (IQR) (and were compared using the Mann-Whitney U test). Main pathophysiological findings derived by real-time CMR in patients with HFpEF and NCD as defined by right heart catheterization. Data are presented according to the patients’ sex. BoldP values indicate statistical significance below 0.05.
BSA = body surface area; EF = ejection fraction; LA = left atrium; LV/RV = left/right ventricular.