Table 1.
Baseline Characteristics
| Overall Cohort (N = 252) | Primary Prevention (n = 204) | Secondary Prevention (n = 48) | |
|---|---|---|---|
| Age at TFC fulfillment, y | 39.6 ± 16.9 | 39.1 ± 17.4 | 42.2 ± 14.3 |
| Male | 85 (33.7) | 65 (31.9) | 20 (41.7) |
| Ethnicity | |||
| White Caucasian | 238 (94.4) | 194 (95.1) | 44 (91.7) |
| South Asian | 6 (2.4) | 5 (2.5) | 1 (2.1) |
| African American/Black | 5 (2.0) | 3 (1.5) | 2 (4.1) |
| Hispanic | 2 (0.8) | 2 (0.9) | 0 |
| East Asian | 1 (0.4) | 0 | 1 (2.1) |
| Probands | 151 (59.9) | 113 (55.4) | 38 (79.2) |
| Sustained VA at/prior to TFC fulfillment | 48 (19.0) | - | 48 (100) |
| ECG | |||
| Overall n of TWI | 3 [1-4] | 3 [1-4] | 3 [1-5] |
| TWI in ≥3 precordial leads | 124 (49.2) | 95 (46.6) | 29 (60.4) |
| TWI in ≥2 inferior leads | 45 (17.9) | 36 (17.6) | 9 (20.0) |
| 24-h PVC burden | 2,000 (650-5,000) | 1,920 (612-5,000) | 2,438 (1,180-6,124) |
| 24-h PVC burden ≥500 | 155 (84.9) | 133 (65.2) | 22 (45.8) |
| LVEF at TFC fulfillment | 45.0 ± 13.3 | 46.6 ± 10.5 | 41.5 ± 12.5 |
| RVEF at TFC fulfillment | 46.4 ± 11.2 | 45.8 ± 13.4 | 45.4 ± 13.7 |
| LGE at TFC fulfillment (assessed n = 193/166/33) | 131 (68.2) | 111 (66.9) | 20 (60.6) |
| LV disease involvement | 194 (77.0) | 156 (76.5) | 38 (79.1) |
| Medical therapy at baseline | |||
| BB | 165 (65.5) | 136 (66.7) | 29 (60.4) |
| AAD | 37 (14.7) | 24 (11.8) | 13 (27.1) |
| ACEI/ARB | 113 (44.8) | 89 (43.6) | 24 (50.0) |
| MRA | 38 (15.1) | 29 (14.2) | 9 (18.8) |
| ICD at TFC fulfillment | 118 (46.8) | 81 (39.7) | 37 (77.1) |
Values are mean ± SD, n (%), or median (IQR).
ACEI = angiotensin converting enzyme inhibitor; AAD = anti-arrhythmic drug; ARB = angiotensin receptor blocker; BB = beta blocker; ICD = implantable cardioverter defibrillator; LGE = late gadolinium enhancement; LV = left ventricular; LVEF = left ventricular ejection fraction; MRA = mineralocorticoid receptor antagonist; PVC = premature ventricular contraction; RVEF = right ventricular ejection fraction; TFC = Task Force Criteria; TWI = T-wave inversion; VA = ventricular arrhythmias.