TABLE 1.
Baseline demographic and clinical characteristics of patients. Data are shown for patients with five visits (at least 30 days before a cardiovascular event or death) within the first 2 years, separately for on-treatment SBP-CV quintiles (conventional)
| On-treatment SBP-CV quintiles | ||||||
| All | 1 | 2 | 3 | 4 | 5 | |
| Number of patients | 25390 | 5078 | 5084 | 5072 | 5078 | 5078 |
| SBP-CV, % | 8.8 ± 4.0 | 3.9 ± 1.0 | 6.4 ± 0.6 | 8.3 ± 0.6 | 10.5 ± 0.8 | 15.0 ± 2.8 |
| Northern hemisphere, % | 81.3 | 83.7 | 82.1 | 81.4 | 80.6 | 78.5 |
| Age, years | 66.2 ± 7.1 | 65.6 ± 7.0 | 66.5 ± 7.0 | 66.1 ± 7.1 | 66.5 ± 7.1 | 67.2 ± 7.1 |
| Males, % | 70.8 | 72.6 | 72.1 | 72.4 | 69.2 | 67.6 |
| Whites, % | 71.7 | 75.3 | 73.8 | 71.5 | 69.9 | 68.0 |
| BMI, kg/m2 | 28.1 ± 4.7 | 28.3 ± 4.8 | 28.2 ± 4.7 | 28.2 ± 4.6 | 28.0 ± 4.6 | 27.9 ± 4.7 |
| Baseline SBP, mm Hg | 141.5 ± 17.1 | 141.6 ± 15.9 | 141.2 ± 16.8 | 141.4 ± 17.3 | 141.4 ± 17.3 | 141.9 ± 18.4 |
| Baseline DBP, mm Hg | 82.1 ± 10.3 | 82.8 ± 9.7 | 82.3 ± 10.2 | 82.2 ± 10.1 | 81.9 ± 10.4 | 81.5 ± 10.9 |
| Baseline HR, bpm | 67.7 ± 12.1 | 68.7 ± 11.7 | 67.9 ± 12.1 | 67.7 ± 12.1 | 67.2 ± 12.1 | 67.2 ± 12.3 |
| Serum creatinine, mg/dl | 1.05 ± 0.26 | 1.04 ± 0.25 | 1.04 ± 0.24 | 1.05 ± 0.26 | 1.06 ± 0.27 | 1.07 ± 0.29 |
| eGFR, ml/min per 1.73 m2 | 74.0 ± 19.6 | 74.6 ± 19.6 | 74.9 ± 19.2 | 74.3 ± 19.4 | 73.4 ± 19.4 | 72.6 ± 20.2 |
| Obesity, % | 32.6 | 33.5 | 32.6 | 32.6 | 32.5 | 31.6 |
| Current smoking, % | 11.8 | 11.3 | 11.3 | 12.0 | 12.2 | 12.1 |
| Alcohol consumption, % | 39.7 | 41.5 | 40.2 | 40.0 | 40.1 | 36.9 |
| Physical activity, % | ||||||
| Mainly sedentary | 21.9 | 22.4 | 21.7 | 20.7 | 21.2 | 23.3 |
| <once/week | 11.1 | 11.4 | 12.1 | 10.2 | 10.5 | 11.3 |
| 2–6 times/week | 31.0 | 31.9 | 29.9 | 31.9 | 31.8 | 29.6 |
| Everyday | 36.0 | 34.3 | 36.3 | 37.2 | 36.5 | 35.8 |
| Hypertension, % | 69.7 | 69.6 | 68.6 | 68.9 | 69.1 | 72.3 |
| Diabetes mellitus, % | 35.9 | 37.0 | 34.8 | 35.5 | 35.8 | 36.4 |
| Previous MI, % | 48.5 | 49.0 | 48.8 | 47.8 | 49.2 | 47.7 |
| Previous stroke/TIA, % | 20.3 | 19.5 | 19.2 | 20.2 | 20.4 | 22.1 |
| Use of beta blockers, % | 58.0 | 56.2 | 57.4 | 56.7 | 58.5 | 61.4 |
| Use of diuretics, % | 27.3 | 25.6 | 26.6 | 25.8 | 27.8 | 30.9 |
| Use of CCBs, % | 25.5 | 26.5 | 26.0 | 25.1 | 25.4 | 24.4 |
| Participation in ONTARGET, % | 81.2 | 78.9 | 79.6 | 81.8 | 81.6 | 83.9 |
| Study treatment, % | ||||||
| Placebo | 9.3 | 11.2 | 10.5 | 9.3 | 8.3 | 7.3 |
| Ramipril | 27.4 | 26.9 | 28.3 | 27.6 | 27.6 | 26.5 |
| Telmisartan | 36.7 | 38.5 | 37.5 | 36.9 | 36.2 | 34.5 |
| Telmisartan + ramipril | 26.5 | 23.4 | 23.7 | 26.1 | 27.8 | 31.7 |
| Adherence to study treatment, % | ||||||
| <50% | 3.3 | 2.2 | 3.3 | 2.8 | 3.8 | 4.3 |
| 50–<100% | 8.3 | 5.8 | 7.1 | 8.1 | 9.2 | 11.5 |
| 100% | 88.4 | 91.9 | 89.6 | 89.1 | 87.0 | 84.2 |
| On-T SBP, mmHg | 135.2 ± 14.3 | 135.6 ± 13.4 | 135.2 ± 14.0 | 135.2 ± 14.2 | 134.8 ± 14.7 | 135.4 ± 15.0 |
| On-T DBP, mmHg | 77.7 ± 8.1 | 78.7 ± 7.6 | 78.1 ± 7.9 | 77.5 ± 8.1 | 77.2 ± 8.2 | 76. 8 ± 8.5 |
| On-T HR, bpm | 68.9 ± 9.4 | 69.5 ± 8.8 | 69.1 ± 9.4 | 68.6 ± 9.4 | 68.6 ± 9.5 | 68.5 ± 9.8 |
Data are shown as mean ± standard deviation or %. BP and HR values during treatment are included.
BMI, body mass index; CV, coefficient of variation; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate (MDRD formula); HR, heart rate; MI, myocardial infarction; SBP, systolic blood pressure; T, treatment; TIA, transient ischemic attack.