TABLE 2.
Hazard ratios and 95% confidence intervals (CI) for the primary and secondary endpoints of the ONTARGET and TRANSCEND trials according to quintiles of SBP-CV (conventional and residual). Quintile 1 is taken as reference (Ref). P-values (trend) refer to the hazard ratios from quintile 1 to 5. Comparisons between models was made by the Vuong test. Hazard ratios are adjusted for confounders shown in TABLE 1 (using values at the end of the 2-year quantification period whenever appropriate)
| Quintiles yearly event rate/hazard ratio (95% CI) | |||||||
| Parameter | 1 | 2 | 3 | 4 | 5 | P-value (trend) | Vuong-test (conv. vs. resid.) |
| Primary endpoint | |||||||
| SBP-CV conventional |
3.17 Ref |
3.32 1.06 (0.93–1.21) |
3.42 1.06 (0.93–1.21) |
3.71 1.12 (0.98–1.27) |
4.09 1.16 (1.02–1.32) |
0.21 | 0.32 |
| SBP-CV residual |
3.16 Ref |
3.28 1.03 (0.90–1.18) |
3.47 1.07 (0.94–1.22) |
3.56 1.08 (0.94–1.23) |
4.24 1.20 (1.05–1.36) |
0.060 | |
| Cardiovascular death | |||||||
| SBP-CV conventional |
1.21 Ref |
1.36 1.14 (0.93–1.41) |
1.27 1.04 (0.84–1.29) |
1.52 1.18 (0.97–1.45) |
1.79 1.31 (1.07–1.60) |
0.062 | 0.78 |
| SBP-CV residual |
1.18 Ref |
1.31 1.12 (0.91–1.38) |
1.39 1.16 (0.94–1.43) |
1.44 1.16 (0.94–1.43) |
1.83 1.36 (1.12–1.67) |
0.041 | |
| Myocardial infarction | |||||||
| SBP-CV conventional |
0.92 Ref |
0.89 0.97 (0.76–1.25) |
0.98 1.07 (0.84–1.36) |
0.98 1.05 (0.82–1.34) |
1.01 1.05 (0.82–1.34) |
0.95 | 0.97 |
| SBP-CV residual |
0.95 Ref |
0.88 0.93 (0.72–1.19) |
0.94 0.98 (0.77–1.26) |
0.98 1.01 (0.79–1.29) |
1.03 1.03 (0.81–1.32) |
0.93 | |
| Stroke | |||||||
| SBP-CV conventional |
0.82 Ref |
0.70 0.87 (0.66–1.13) |
0.81 0.96 (0.74–1.24) |
0.94 1.10 (0.86–1.42) |
0.98 1.08 (0.84–1.39) |
0.48 | 0.50 |
| SBP-CV residual |
0.79 Ref |
0.77 0.97 (0.74–1.27) |
0.81 0.99 (0.76–1.30) |
0.87 1.06 (0.81–1.37) |
1.02 1.16 (0.90–1.48) |
0.66 | |
| HF hospitalization | |||||||
| SBP-CV conventional |
0.69 Ref |
0.85 1.24 (0.94–1.62) |
0.78 1.10 (0.84–1.46) |
0.85 1.11 (0.84–1.46) |
1.03 1.24 (0.95–1.61) |
0.48 | 0.83 |
| SBP-CV residual |
0.69 Ref |
0.79 1.13 (0.86–1.49) |
0.80 1.13 (0.86–1.48) |
0.82 1.09 (0.83–1.43) |
1.09 1.29 (1.00–1.68) |
0.39 | |
| All-cause mortality | |||||||
| SBP-CV conventional |
2.17 Ref |
2.17 1.00 (0.85–1.18) |
2.27 1.01 (0.86–1.18) |
2.61 1.11 (0.95–1.29) |
3.24 1.28 (1.10–1.49) |
0.0018 | 0.40 |
| SBP-CV residual |
2.14 Ref |
2.10 0.98 (0.83–1.15) |
2.40 1.08 (0.93–1.27) |
2.53 1.10 (0.94–1.18) |
3.28 1.31 (1.13–1.52) |
0.0005 | |
Abbreviations as in the preceding table.