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. 2024 Jun 12;6(6):1178–1196. doi: 10.1038/s42255-024-01043-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Phenotypic changes observed in the MASLD models compared to their matched controls were profiled as the log₂ fold change (log₂FC) across measures of BW, blood triglycerides (TGs) and cholesterol, LW:BW% ratio, and ALT and AST. The red–blue color gradient indicates the level of increase–decrease of the measure in the MASLD models compared to their controls, while an asterisk indicates a significant change at P < 0.05 (two-sided Mann–Whitney U-test). The two panels of horizontal bars give an overview of the complete histological profiles, in which the total length indicates the activity score (CRN NAS) and fibrosis²⁵. In addition, NAS components (steatosis, ballooning and inflammation) are represented by the stacked bar (yellow, green and blue, respectively) lengths. All models are grouped according to their macro-categories (detailed by the leftmost annotations).

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