Fig. 5. Highly performing genes in human and murine MASLD.
Selection of statistically significant DEGs (complete list in Supplementary Table 4) enriching statistically significant modulated pathways (complete list in Fig. 3), thus being highly biologically relevant genes associated with the different stages of MASLD development or progression. To assess the statistical significance between the compared groups, a Wald test statistic (two-sided hypothesis testing) was deployed to compare the coefficients of explanatory variables in a regression model, representing the gene expression differences among the compared groups. The human and murine datasets are represented in a color-scale matrix showing the log2FC. * and $ symbols denote statistical significance ($, P < 0.05; *, adjusted P < 0.05 (Benjamini–Hochberg correction)). As the graphic legend indicates, all models were grouped according to their macro-categories.