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. 2024 Jun 25;7:167. doi: 10.1038/s41746-024-01170-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Exploration of the underlying biology through a phenome-wide association study (PheWAS) in the BIDMC cohort: a A PheWAS Manhattan plot showing the negative logarithm of the univariate logistic regression p-values between delta-BMI and disease phecodes, adjusted for measured BMI, sex, age, and age². The dashed horizontal line signifies the Bonferroni corrected threshold for multiple comparisons. Out of 1408 comparisons, 55 (3.9%) reached significance based on the Bonferroni correction. An interactive version of the plots can be accessed in the Online Supplement. b Illustrates the top 20 significant phecodes associated with delta-BMI, presenting their respective odds ratios with 95% CI. ASCVD atherosclerotic cardiovascular disease.