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Study design and EAE score. (A) Mice were treated with a weekly dose of 100 μg of aCD20 mAb (n = 2) or isotype control (n = 3). On day 30-35, mice were dissected, and cell surface protein (CSP) and gene expression (GEX) libraries prepared and sequenced using 10x Genomics technology before bioinformatics analyses. (B) Daily evaluated EAE scores over the experimental period. Error bars show +/- SEM for the control group only.
