TABLE 2.
Summary of lacZ cDNA transduction in each of three distinct intracerebral tumors at 2 days after the intravascular administration of hrR3 in the presence (+) or absence (−) of CVF and RMP7
| CVF | RMP7 | No. of positive tumors/ total no. of tumorsa | Avg % area of transduction in positive tumorsb |
|---|---|---|---|
| + | + | 10/12 | 3.2c |
| + | − | 5/9 | 3.5 |
| − | + | 1/9 | 2.3 |
| − | − | 0/9 | 0 |
a
Three tumors (right frontal and thalamic and left frontal) were established in each animal.
b
Percentages were calculated by computer-assisted analysis of lacZ-expressing tumor area, as determined 2 days after the intravascular administration of hrR3, divided by the total tumor area.
c
Values represent the mean transduced tumor area from five randomly selected sections analyzed in a blinded fashion by S.J.