TABLE 3.

Summary of lacZ cDNA transduction in each of three distinct intracerebral tumors at 4 days after the intravascular administration of hrR3 in the presence (+) or absence (−) of CVF and CPA^a

CVF	CPA	No. of positive tumors/ total no. of tumorsb	Avg % area of transduction in positive tumorsc
+	+	8/9	64
+	−	5/9	1.2
−	+	1/9	45
−	−	0/9	0

^aAll animals were treated with RMP7. CPA was administered 2 days after the intravascular injection of hrR3 and the second injection of CVF. The timing of CPA administration differs from the one previously reported (35), where CPA was administered the same day as virus, thus accounting for the difference in results. 

^bThree tumors (right frontal and thalamic and left frontal) were established in each animal. 

^cPercentages were calculated by computer-assisted analysis of lacZ-expressing tumor area, as determined 2 days after the intravascular administration of hrR3, divided by the total tumor area. Values represent the mean transduced tumor area from five randomly selected sections analyzed in a blinded fashion by S.J.