Figure 4.

Physical erosion of XTEN‐based coiled‐coil gels in PBS. a) Photographs of each gel type following 0, 3, 6, and 12 days in PBS at 37 °C. The slowest degradation was observed in the T40A+Q54A mutant. Some of the original gel remains visually intact after 12 days for all formulations. b) BCA analysis of % gel degraded into PBS solution throughout 12 days of maintenance in PBS at 37 °C, with the PXP gels reaching plateau values significantly sooner than the mutant variants. Slower degradation is observed with the introduction of point mutations, with the slowest degradation being T40A+Q54A. Error bars reported as SEM, N = 3.