TABLE 2.

Capsid amino acid differences among CVB3 isolates

Protein	Amino acid positiona	Amino acid at that position in strainb:
		AS	CO	20	N	0	H3	M
VP4	4016	G	G	R	R	G	G	G
	4018	S	N	N	N	N	N	N
	4030	I	I	I	I	V	I	I
	4042	N	T	N	N	N	N	N
	4047	A	A	T	T	T	T	T
	4051	G	G	G	G	G	S	S
VP2	2013	V	V	V	A	A	V	V
	2045	S	N	S	S	S	S	S
	2108	I	I	V	V	V	I	I
	2138*	D	D	D	D	D	N	N
	2144*	A	E	A	A	A	A	A
	2151*	S	A	S	T	S	S	S
	2171	V	A	V	V	V	V	V
	2179	V	I	V	V	V	V	V
	2245	V	V	V	V	V	I	I
VP3	3046	I	I	I	I	I	I	V
	3058*	I	I	V	V	V	V	V
	3062*	I	V	V	V	V	V	V
	3078*	S	T	S	S	S	S	S
	3155	V	V	V	I	V	V	V
	3178	Y	Y	F	F	Y	Y	Y
	3234*	Q	Q	Q	Q	E	Q	Q
	3237*	F	L	F	F	F	F	F
VP1	1007	V	I	I	I	I	I	I
	1045	S	G	G	G	G	S	S
	1064	V	I	I	I	I	I	I
	1080*	E	E	K	K	E	E	E
	1084	A	S	A	A	A	A	A
	1085*	K	N	K	K	K	K	K
	1092	I	I	L	L	L	I	I
	1094	P	T	P	P	P	P	P
	1098	A	V	A	A	A	A	A
	1110	V	M	V	V	V	V	V
	1180	I	I	I	I	I	V	V
	1200*	S	A	S	S	S	S	S
	1223*	T	A	A	A	A	A	A
	1264*	Q	Q	R	Q	Q	Q	Q

^aAmino acid position relative to the CVB3/20 strain (46). Surface-exposed residues of CVB3/M determined by X-ray crystallography (31) are marked with asterisks. 

^bData for strains N, 0, H3, and M are from references 21, 5, 22, and 23, respectively.