. 2024 Jun 25;7(6):e2417786. doi: 10.1001/jamanetworkopen.2024.17786

Table 2. Baseline Features Associated With Differential Improvement in Depression Severity With Ketamine vs Electroconvulsive Therapy.

Measure by treatment-by-time interaction	F test	df ^a	P value
QIDS-SR16 ^b
NAART-35 standardized score^c	1.38	6/2004	.22
Baseline QIDS-SR16 score^b	3.19	6/2021	.004^d
MoCA score^e	1.22	6/2020	.29
HVLT-R delayed recall T score^f	0.56	6/2015	.76
Concurrent benzodiazepine use	1.16	6/2020	.33
Concurrent atypical antipsychotic medication use	1.02	6/2021	.41
BMI	1.31	6/1940	.25
History of suicide attempt	0.54	6/2021	.78
Inpatient status at first treatment	3.95	6/2021	<.001^d
Presence of anxious features	0.50	6/2021	.81
Comorbid PTSD diagnosis	0.66	6/2021	.69
MADRS ^g
NAART-35 standardized score^c	2.07	6/2005	.05
Baseline MADRS score^g	3.03	6/2016	.006
MoCA score^e	1.27	6/2020	.27
HVLT-R delayed recall T score^f	1.39	6/2016	.22
Concurrent benzodiazepine use	0.97	6/2021	.44
Concurrent atypical antipsychotic medication use	1.68	6/2022	.12
BMI	1.25	6/1941	.28
History of suicide attempt	0.24	6/2022	.96
Inpatient status at first treatment	1.73	6/2022	.11
Presence of anxious features	0.84	6/2022	.54
Comorbid PTSD diagnosis	0.72	6/2022	.63

Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); HVLT-R, Hopkins Verbal Learning Test-Revised; MADRS, Montgomery-Åsberg Depression Rating Scale; MoCA, Montreal Cognitive Assessment; NAART-35, North American Adult Reading Test-35; PTSD, posttraumatic stress disorder; QIDS-SR16, 16-item Quick Inventory of Depressive Symptomatology Self-Report.

^{^a}

Presented as numerator df/denominator df.

^{^b}

Scores range from 0 to 27, with more than 20 indicating very severe depression.

^{^c}

Scores range from 57 to 113 in the ELEKT-D: Electroconvulsive Therapy (ECT) vs Ketamine in Patients With Treatment Resistant Depression (TRD) (ELEKT-D) trial, with higher scores indicating higher premorbid intelligence.

^{^d}

Significant after false discovery rate correction for multiple comparisons.

^{^e}

Scores range from 0 to 30, with higher scores indicating normal cognition.

^{^f}

Scores range from −11 to 62 in ELEKT-D, with higher scores indicating better functioning.

^{^g}

A 10-item clinician-rated scale, ranging from 0 to 60, in which a score greater than 36 indicates very severe depression.