Table 1. Characteristics of Cohort Donors That Donated at Least 1 Lung for Transplant.
| Characteristic | Donors, No. (%) (N = 1651)a | P value | |
|---|---|---|---|
| Hospital-based DCU (n =418) | Independent DCU (n = 1233) | ||
| DCUs, No./Total No. | 11/21 (52.4) | 10/21 (47.6) | NA |
| Donation year, No./Total No. (%) | |||
| April to December 2017 | 28/102 (27.4) | 74/102 (72.5) | .02 |
| 2018 | 39/204 (19.1) | 165/204 (80.9) | |
| 2019 | 47/248 (19.0) | 201/248 (81.0) | |
| 2020 | 92/340 (27.1) | 248/340 (72.9) | |
| 2021 | 125/462 (27.1) | 337/462 (72.9) | |
| January to June 2022 | 87/295 (29.5) | 208/295 (70.5) | |
| Age, mean (SD), y | 36.1 (13.1) | 36.3 (12.8) | .80 |
| Sexb | |||
| Female | 163 (39.0) | 490 (39.7) | .79 |
| Male | 255 (61.0) | 743 (60.3) | |
| Race and ethnicityb | |||
| American Indian or Alaska Native | 2 (0.5) | 5 (0.4) | <.001 |
| Asian | 23 (5.5) | 11 (0.9) | |
| Black | 78 (18.7) | 245 (19.9) | |
| Hispanic | 93 (22.2) | 162 (13.1) | |
| Multiracial | 5 (1.2) | 5 (0.4) | |
| Native Hawaiian or Other Pacific Islander | 1 (0.2) | 1 (0.1) | |
| White | 216 (51.7) | 804 (65.2) | |
| History of tobacco use | 29 (6.9) | 118 (9.6) | .26 |
| History of cocaine use | 69 (16.5) | 258 (20.9) | .03 |
| History of other drug use | 225 (53.8) | 697 (56.5) | .62 |
| Clinical characteristics | |||
| Donor height, median (IQR), cm | 172 (163-179) | 173 (165-180) | .15 |
| Body mass index, median (IQR)c | 25.8 (22.5-29.6) | 26.3 (22.9-30.3) | .003 |
| Mechanism of death | |||
| Asphyxiation | 32 (7.7) | 53 (4.3) | .03 |
| Blunt injury | 84 (20.1) | 233 (18.9) | |
| Cardiovascular | 38 (9.1) | 125 (10.1) | |
| Death from natural causes | 8 (1.9) | 28 (2.3) | |
| Drowning | 2 (0.5) | 6 (0.5) | |
| Drug intoxication | 59 (14.1) | 255 (20.7) | |
| Electrical | 0 | 2 (0.2) | |
| Gunshot wound | 85 (20.3) | 204 (16.5) | |
| Intracranial hemorrhage or stroke | 105 (25.1) | 295 (23.9) | |
| Other | 1 (0.2) | 9 (0.7) | |
| Seizure | 4 (1.0) | 21 (1.7) | |
| Stab | 0 | 2 (0.2) | |
| Terminal Pao2:Fio2 ratio, mm Hg, median (IQR) | 439 (360-507) | 447 (361-502) | .53 |
| Pulmonary infection | 325 (77.8) | 838 (68.0) | <.001 |
Abbreviations: DCU, donor care unit; NA, not applicable; Pao2:Fio2, ratio of partial pressure of oxygen in arterial blood to the fraction of inspiratory oxygen concentration.
a
Not all cohort donors donated lungs to a lung transplant recipient included in survival analysis (see cohort selection diagram).
b
As classified by the Organ Procurement and Transplantation Network.13
c
Body mass index was calculated as weight in kilograms divided by height in meters squared.