FIG. 1.

Diagram of the domain structure and mutations of HIV-1 IN. The amino acid sequences of HIV-1 strains (NL43, HXB2, JR-CSF, MN, and SF2), HIV-2ROD and SIVmac239 were obtained from GenBank. The accession numbers of HIV-1 NL43, HXB2, JR-CSF, MN, SF2, HIV-2ROD, and SIVmac239 are M19921, K03455, M38429, M17449, K02007, M15390, and M33262, respectively. Portions of the central catalytic domain and the C-terminal domain are shown. Symbols above the sequence are indicated positions of mutation (shaded triangle, possible site of phosphorylation by CK-II; striped triangle, possible site of phosphorylation by PKC; closed triangle, Tyr residue; open triangle, residues conserved in putative NLS (30) indicated with underlines.