Table 3.

Histopathology findings after either 4 or 8 weeks of antibiotic treatment.

Treatment Group
Saline	-Marked multifocal lymphocytic and plasma cell infiltration, diffuse congestion.
	-Dense infiltration of lymphocytes, plasma cells, and macrophages; infiltration of the blood vessels; formation of nodes or granulomas with many bacteria.
	-Bacteria in the tissue, nodes, and mucosal area.
Clarithromycin	-Moderate multifocal lymphocytic and plasma cells in the adventitia of multifocal pulmonary blood vessels, forming nodular aggregates or granulomas with bacteria.
	-Perivascular inflammation, with minimal peribronchiolar lymphocytic infiltration.
	-Diffuse congestion, bacteria in granulomas.
Rifabutin	-Diffuse congestion.
	-Moderate and sometimes marked infiltration of lymphocytes and plasma cells in the adventitia of multiple pulmonary blood vessels, formation of granulomas and aggregates with bacteria.
	-Infiltrates of lymphocytes are also observed in multiple locations in the bronchi and bronchioles.
Clofazimine	-Mild diffuse congestion.
	-Minimal multifocal congestion of lymphocytes and plasma cells.
	-Granulomas in multiple locations with a mild number of bacteria.
	-Infiltration into the bronchiolar walls.
Clarithromycin	-Multidiffuse congestion.
+Clofazimine	-Minimal multifocal infiltration of lymphocytes and plasma cells in the lung tissue and in the bronchiole walls.
	-Limited number of granulomas with few bacteria.
Clarithromycin	-Mild to moderate and sometimes marked infiltration of the adventitia of multiple pulmonary blood vessels with lymphocytes and plasma cells, formation of nodular aggregates with bacteria.
+Rifabutin	-Infiltration in the walls of the airways.
Clarithromycin	-Minimal diffuse congestion.
+Rifabutin	-Minimal multifocal infiltration of lymphocytes, with occasional plasma cells in the bronchial walls.
+Clofazimine	-Rare, resolving granulomas.