Table 2.

Antibiotic resistance genes identified by WGS of isolates 1, 2, 3, 4 and 10.

Strain/MLST	ARGs						Chromosomal Mutations
	β-Lactams	Macrolide	Quinolone	Aminoglycoside	Fosfomycin	Others
1/ST512	blaKPC-3, blaSHV-11	mph(A)	oqxAB	aac(6′)-Ib, aadA2b	fosA5	sul1, qacE	acrR	P161R, G164A, F172S, R173G, L195V, F197I, K201M (fluoroquinolones)
							ompK36	A217S (carbapenems) N49S, L59V, G189T, F198Y, F207Y, T222L, D223G, E232R, N304E (cephalosporins)
							ompK37	I70M, I128M, N230G (carbapenems)
2/ST307	blaKPC-2, blaSHV-28, blaCTX-M-15, blaOXA-1	none	oqxAB, aac(6′)-Ib-cr, qnrB1	aac(6′)-Ib-cr	fosA5	sul1, catB3, dfrA14	acrR	P161R, G164A, F172S, R173G, L195V, F197I, K201M (fluoroquinolones)
							ompK36	N49S, L59V, T184P (cephalosporins)
							ompK37	I70M, I128M, N230G (carbapenems)
3/ST101	blaKPC-3, blaSHV-28, blaCTX-M-15, blaOXA-1, blaTEM-1B	none	aac(6′)-Ib-cr, oqxAB, qnrB1	aac(6′)-Ib-cr, aph(6)-Id, aph(3″)-Ib, aac(3)-IIa	fosA	catB3, sul2, tet(A) dfrA14	ompK36	A217S, N218H (carbapenems) N49S, L59V, L191S, F207W, D224E, L228V, E232R, T254S (cephalosporins)
							ompK37	I70M, I128M (carbapenems)
4/ST307	blaKPC-2, blaSHV-28, blaCTX-M-15, blaOXA-10, blaOXA-1	mph(A)	oqxAB, aac(6′)-Ib-cr	aac(6′)-Ib-cr, aadA24, aadA1, ant(2″)-Ia	fosA6, fosA5	sul1, cmlA1, catB3, ARR-2, dfrA12, dfrA14, qacE	acrR	P161R, G164A, F172S, R173G, L195V, F197I, K201M (fluoroquinolones)
							ompK36	N49S, L59V, T184P (cephalosporins)
							ompK37	I70M, I128M, N230G (carbapenems)
10/ST unknown	blaKPC-2, blaTEM-1B, blaCTX-M-14	mph(A)	none	aadA5, aph(6)-Id, aph(3″)Ib, aac(3)-IId	none	sul1, sul2, tet(A), dfrA17	gyrA	S83L, D87N (ciprofloxacin)
							parC	S80I (ciprofloxacin)