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. 2024 May 29;13(6):667. doi: 10.3390/antiox13060667

Figure 8.

Figure 8

PIT made FLC fungicidal by disrupting membrane integrity. (A) The nucleic acid leakage in C. albicans SN152 after 4 μg/mL FLC, 2 μM PIT alone, and FLC and PIT combination for 4 h. Amphotericin B (2 μM) was regarded as the positive control. (B) The extracellular protein content in C. albicans SN152 after 4 μg/mL FLC, 2 μM PIT alone, and FLC and PIT combination for 4 h. Amphotericin B (2 μM) was regarded as the positive control. (C) MIC assays in YPD medium with PIT (0, 0.5, 1 μM) showed that the age3Δ/age3Δ mutant was more sensitive to FLC than other strains. (D) The age3Δ/age3Δ strain showed significant sensitivity to the combination of FLC and PIT using spotting assay analysis.