Table 1.
Demographics and plasma biomarker concentrations
| Cognitively Unimpaired, N = 66 | MCI, N = 130 | Dementia, N = 94 | P value | |
|---|---|---|---|---|
| Age | 57 (12) | 73 (11) | 75 (9) | < 0.001 |
| Sex (Female) | 46 (70%) | 77 (59%) | 57 (61%) | 0.3 |
| MMSE | 29.0 (1.0) | 26.0 (4.0) | 22.0 (5.8) | < 0.001 |
| APOEε4 | 15 (23%) | 32 (25%) | 36 (38%) | 0.042 |
| Plasma pTau217 (pg/mL) | 0.11 (0.08) | 0.23 (0.35) | 0.46 (0.63) | < 0.001 |
| Plasma pTau181 (pg/mL) | 1.71 (0.55) | 2.32 (1.28) | 3.35 (1.86) | < 0.001 |
| Plasma Aβ1-42 (pg/mL) | 25.0 (4.6) | 23.0 (5.0) | 24.6 (6.2) | 0.028 |
| Plasma Aβ1-40 (pg/mL) | 290 (65) | 301 (66) | 319 (72) | < 0.001 |
| Plasma Aβ1-42/Aβ1-40 | 0.085 (0.010) | 0.076 (0.014) | 0.074 (0.008) | < 0.001 |
| A | < 0.001 | |||
| A + | 5 (7.6%) | 66 (51%) | 69 (73%) | |
| AT | < 0.001 | |||
| A-T- | 61 (92%) | 64 (49%) | 25 (27%) | |
| A + T- | 2 (3.0%) | 17 (13%) | 12 (13%) | |
| A + T + | 3 (4.5%) | 49 (38%) | 57 (61%) | |
| Etiology | < 0.001 | |||
| CU | 56 (85%) | 0 (0%) | 0 (0%) | |
| AD | 4 (6.1%) | 43 (33%) | 50 (53%) | |
| OtherNotDeg | 1 (1.5%) | 37 (28%) | 11 (12%) | |
| OtherDem | 3 (4.5%) | 18 (14%) | 20 (21%) | |
| Uncertain | 2 (3.0%) | 32 (25%) | 13 (14%) | |
| VRF | 39 (60%) | 102 (82%) | 75 (85%) | < 0.001 |
| HBP | 24 (37%) | 71 (57%) | 49 (56%) | 0.021 |
| DM | 11 (17%) | 28 (23%) | 20 (23%) | 0.6 |
| DLP | 21 (32%) | 64 (52%) | 55 (63%) | 0.001 |
| eGFR(mL/min/1.73m3) | < 0.001 | |||
| > 90 | 36 (64%) | 29 (23%) | 13 (14%) | |
| 60–90 | 18 (32%) | 91 (71%) | 68 (72%) | |
| < 60 | 2 (3.6%) | 8 (6.3%) | 13 (14%) |
Median (IQR); n (%)
Kruskal–Wallis rank sum test was used to compare continuous variables that were not normally distributed; Pearson’s Chi-squared test was used to compare categorical variables; Fisher’s exact test was used to compare categorical variables with small number of observations
Unless otherwise specified, values are presented as median (IQR)
CU Cognitively Unimpaired, MCI Mild cognitive impairment, AD Alzheimer disease, OtherNotDeg Other not degenerative, OtherDem Other diseases, VRF one or more vascular risk factors, HBP High blood pressure, DM Diabetes mellitus, DLP Dyslipidemia, eGFR Estimated glomerular filtration rate