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Chemical structures of NNRTI Rilpivirine (RPV). The torsion angles defining the rotatable bonds are labeled using purple-colored arrows in Karaviloside VIII, X, and XI. The equivalent torsion angle RPV is labeled using magenta-colored arrows. The structures of karavilosides, apart from karaviloside VIII, can be divided into three functional regions—a steroidal central ring, a hexose sugar/ethylene glycol left wing, and a hexose sugar right wing.
