Table 3.

Median age and IQR of the first occurrence of cardiovascular manifestations in patients with LMNA mutations.

Cardiovascular Manifestation	Median Age [IQR]
Cardiac death	57 [52–63]
Heart transplantation	55 [49–61]
Appropriate ICD interventions	53 [47–59]
1st degree AVB	41 [35–49]
2nd degree AVB	37 [35–49]
3rd degree AVB	54 [52–59]
AF	49 [43–53]
AFL	48 [43–50]
NSVT	48 [36–52]
SVT/VF	54 [47–59]
Dilated phenotype	50 [44–59]
Mild LV disfunction	48 [38–52]
Moderate LV disfunction	52 [47–58]
Severe LV disfunction	54 [47–60]
RV involvement	53 [44–59]

AF = atrial fibrillation; AFL = atrial flutter; AVB = atrioventricular block; ICD = implantable cardioverter defibrillator; IQR = interquartile range; LMNA = lamin A/C gene; LV = left ventricular; NSVT = non-sustained ventricular tachycardia; RV = right ventricular; SVT = sustained ventricular tachycardia; and VF = ventricular fibrillation.