Table 3.
Clinical outcomes of COVID-19 patients stratified according to having seizure.
| Outcome | With pre-existing seizure/epilepsy (n = 27) | Without pre-existing seizure/epilepsy (n = 10,854) | p value | With new-onset seizure (n = 125) | Without new-onset seizure (n = 10,756) | p value |
|---|---|---|---|---|---|---|
| COVID-19 severity | 0·131 | <0·001 | ||||
| Severe/critical | 14 (51·8 %) | 4047 (37·7 %) | 78 (64·5 %) | 3983 (37·5 %) | ||
| Mild/moderate | 13 (48·2 %) | 6677 (62·2 %) | 43 (35·5 %) | 6647 (62·5 %) | ||
| All-cause mortality | 0·177 | <0·001 | ||||
| Mortality | 7 (25·9 %) | 1695 (15·6 %) | 56 (44·8 %) | 1646 (15·3 %) | ||
| Survivor | 20 (74·1 %) | 9159 (84·3 %) | 69 (55·2 %) | 9110 (84·7 %) | ||
| Neurologic outcomesa | 0·190 | 0·007 | ||||
| Full/partial improvement | 8 (72·7 %) | 1631 (86·1 %) | 68 (76·4 %) | 1571 (86·5 %) | ||
| Stable, no improvement | 3 (27·3 %) | 263 (13·9 %) | 21 (23·6 %) | 245 (13·5 %) | ||
| Use of a ventilator | 0·106 | <0·001 | ||||
| Yes | 7 (25·9 %) | 1601 (14·8 %) | 60 (48·0 %) | 1548 (14·4 %) | ||
| No | 20 (74·1 %) | 9253 (85·3 %) | 65 (52·0 %) | 9208 (85·6 %) | ||
| Length of ICU stayb,c | 19·5 (11·5) | 15 (12) | 0·276 | 15 (10·5) | 15 (12) | 0·996 |
| Length of hospital stayc | 12 (7) | 13 (9) | 0·591 | 15 (10) | 13 (9) | 0·059 |
COVID-19 – Coronavirus disease 2019; ICU – intensive care unit.
a
Only 1905 participants have neurologic outcome data among the 2291 participants with neurologic presentation and/or complication.
b
Among 1740 participants who have been admitted in the ICU.
c
Data presented is median (interquartile range).