WHO	World Health Organization
CNS	Central nervous system
ALL	Acute lymphoblastic leukemia
AML	Acute myeloid leukemia
JAK	Janus kinases
STAT	Signal transducer and activator of transcription
PI3K	Phosphoinositide 3-kinases
ALK	Anaplastic lymphoma kinase
NF1	Neurofibromatosis type 1
PTEN	Phosphatase and tensin homolog
FLT3	FMS-like tyrosine kinase 3
PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha or p110α
PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1
CDKN2A	Cyclin-dependent kinase Inhibitor 2A
TME	Tumor microenvironment
TILs	Tumor-infiltrating lymphocytes
Tregs	Regulatory T cells
NK cells	Natural killer cells
DCs	Dendritic cells
MDSCs	Myeloid-derived suppressor cells
ECM	Extracellular matrix
mAbs	Monoclonal antibodies
CAR	Chimeric antigen receptor
TAMs	Tumor-associated macrophages
TMB	Tumor mutational burden
LGG	Low-grade gliomas
HGG	High-grade gliomas
IFNγ	Interferon-gamma
CSF1R	Colony stimulating factor 1 receptor
CTLs	Cytotoxic T lymphocytes
PMN	Polymorphonuclear
PD-L1	Programmed death ligand-1
IL6	Interleukin 6
ES	Ewing sarcoma
TNF-α	Tumor necrosis factor-alpha
CTLA-4	Cytotoxic T-lymphocyte-associated protein 4
PD-1	Programmed cell death protein 1
MRD	Minimal residual disease
HSCT	Hematopoietic stem cell transplantation
GM-CSF	Granulocyte-macrophage colony-stimulating factor
SCT	Stem-cell transplantation
COG	Children’s oncology group
ADCC	Antibody-dependent cellular cytotoxicity