ALK |
anaplastic lymphoma kinase |
ATC |
anaplastic thyroid cancer |
CEA |
carcinoembryonic antigen |
CRC |
colorectal cancer |
CTLA-4 |
cytotoxic T-lymphocyte-associated protein 4 |
DCs |
dendritic cells |
DCR |
disease control rate |
dMMR |
mismatch repair-deficient |
DOR |
duration of response |
EGFR |
epidermal growth factor receptor |
EML4 |
EMAP-like 4 |
FDA |
United States Food and Drug Administration |
FLT3L |
FMS-like tyrosine kinase 3 ligand |
GDF15 |
growth differentiation factor 15 |
HER2 |
human epidermal growth factor receptor 2 |
HRR |
homologous recombination repair |
IHC |
immunohistochemistry |
InDel |
insertions and deletions |
LIFl |
leukemia inhibitory factor 1 |
MAPK |
Mitogen-activated protein kinase |
MCL1 |
myeloid cell leukemia-1 |
mDOR |
median duration of the response |
MDSC |
myeloid-derived suppressor cells |
MEK1 and MEK2 |
mitogen-activated protein kinase 1 and 2 |
MIP |
molecular imprinting polymers |
MSI-H |
metastatic microsatellite instability-high |
NGR1 |
HER3-targeting arm to block neuregulin 1 |
NGS |
Next-generation sequencing |
NK |
natural killer cell |
NPM1 |
nucleophosmin 1 |
NSCLC |
non-small-cell lung cancer |
NTRK |
neurotrophic receptor tyrosine kinase |
ORR |
objective response rate |
OS |
overall survival |
PD-1 |
programmed death receptor 1 |
PD-L1 |
programmed death ligand 1 |
PFS |
progression-free survival |
P-GP |
P-Glycoprotein |
RET |
rearranged during transfection |
ROS1 |
receptor tyrosine kinase ROS proto-oncogene 1 |
TAAs |
tumor-associated antigens |
TAMs |
tumor-ssociated macrophages |
TNBC |
triple-negative breast cancer |
TCGA |
The Cancer Genome Atlas Program |
TME |
tumor microenvironment |
TLR |
Toll-like receptor |
TMB-H |
high metastatic tumor mutational burden |