Table 1.
Patient Characteristics.
| Metastatic PPGL | Non-Metastatic PPGL | p | |
|---|---|---|---|
| (n = 18) | (n = 27) | ||
|
Age at Initial Diagnosis
(median, range) |
39 (18–65) | 58 (17–80) | 0.01 |
| Sex | |||
| Female | 10 | 18 | 0.537 |
| Male | 8 | 9 | |
| Primary Tumor Location | |||
| Adrenal | 3 | 15 | 0.012 |
| Extra-adrenal | 15 | 12 | |
| Abdominal | 10 | 10 | |
| Head and neck | 2 | 0 | |
| Bladder | 3 | 2 | |
| Functional Status | |||
| Adrenergic | 1 | 12 | 0.012 |
| Noradrenergic | 8 | 4 | |
| Silent or Dopaminergic | 7 | 9 | |
| Not available | 2 | 2 | |
| Diabetes Mellitus | 7 | 5 | 0.175 |
| Hypertension | 10 | 15 | 1 |
| Ki-67 LI | |||
| ≥3% | 14 | 9 | 0.006 |
| <3% | 4 | 18 | |
| Tumor Size | |||
| ≥50 mm | 14 | 13 | 0.065 |
| <50 mm | 4 | 14 | |
| 123I-MIBG Uptake | |||
| Positive | 9 | 24 | 0.007 |
| Negative | 6 | 1 | |
| Not available | 3 | 2 | |
| SDHB Staining | |||
| Positive | 6 | 26 | <0.001 |
| Negative | 12 | 1 |
Abbreviations: PPGL, pheochromocytoma and paraganglioma; Ki-67 LI, Ki-67 labeling index; MIBG, Metaiodobenzylguanidine; SDHB, succinate dehydrogenase subunit B.