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. 2024 Jun 11;16(12):2191. doi: 10.3390/cancers16122191

Table 2.

Characteristics of SSTR2A and HIF-2α expression in PPGLs.

SSTR2A p HIF-2αNUC p
Positive Negative Positive Negative
(n = 21) (n = 24) (n = 14) (n = 31)
Age at Initial Diagnosis
(median, range)
40 (17–70) 59 (18–80) 0.005 41 (17–70) 50 (18–80) 0.333
Sex
Female 15 13 0.356 7 21 0.326
Male 6 11 7 10
Primary Tumor Location
Adrenal 7 11 0.599 0 18 <0.001
Extra-adrenal 14 13 14 13
Abdominal 10 10 11 9
Head and neck 2 0 1 1
Bladder 2 3 2 3
Tumor Site
Adrenal 7 10 0.704 0 17 0.001
Abdominal 10 9 10 9
Liver 0 1 1 0
Head and neck 2 1 1 2
Bladder 2 3 2 3
Functional Status
Adrenergic 6 7 0.743 1 12 0.060
Noradrenergic 7 5 3 9
Silent or Dopaminergic 7 9 8 8
Not available 1 3 2 2
Metastatic PPGL
Yes 12 6 0.037 9 9 0.047
No 9 18 5 22
Ki-67 LI
≥3% 15 8 0.017 13 10 <0.001
<3% 6 16 1 21
GAPP Score
≥7 7 5 0.274 5 7 0.658
3–7 13 14 7 20
<3 1 5 2 4
123I-MIBG Uptake
Positive 14 19 0.226 7 26 0.003
Negative 5 2 6 1
Not available 2 3 1 4
SDHB Staining
Positive 12 20 0.098 4 28 <0.001
Negative 9 4 10 3

Abbreviations: SSTR2A, somatostatin receptor 2A; HIF, hypoxia-induced factor; NUC, nuclear; PPGL, pheochromocytoma and paraganglioma; Ki-67 LI, Ki-67 labeling index; MIBG, Metaiodobenzylguanidine; SDHB, succinate dehydrogenase subunit B; GAPP, Grading of Adrenal Pheochromocytoma and Paraganglioma.