Table 6.

Summary.

The essential role of VMAT2 in preventing dopamine oxidation suggests that its overexpression may be a therapeutic target to develop new drugs that slow the progression of the disease.

Pramipexole is a dopamine agonist used in the therapy of Parkinson’s dis-ease and SPECT studies have demonstrated a neuroprotective effect in patients with Parkin-son’s disease.

Pramipexole induces the expression of VMAT2 mRNA levels