Table 1.

Summary of six different gene ontologies that resulted in the top 30 enriched biological processes from clusterProfiler analysis. For each BP, the relative number of differentially expressed genes (DEGs count), both upregulated (Up DEGs count) and downregulated (Down DEGs count), related to cell cycle pathway, is reported. The Net effect column reports the behavior of each process considering only the cumulative fold change of the DEGs as well as their function. To note, the final effect may also be further regulated by factors not investigated in our analyses.

Gene Ontology Terms	DEGs Count	Up DEGs Count	Down DEGs Count	Hypothesized Net Effect
Chromosome segregation	31	21	10	Activated
Mitotic cell cycle phase transition	38	18	20	Activated
Mitotic nuclear division	29	18	11	Activated
Nuclear chromosome segregation	31	21	10	Activated
Regulation of cell cycle phase transition	35	17	18	Activated
Regulation of chromosome organization	24	13	11	Activated