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. 2024 Jun 25;26:104. doi: 10.1186/s13058-024-01844-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — ICB treatment response varies in MMTV-HER2 and 4T1 mouse models. A) Experimental timeline. B) Tumor growth curve of MMTV-HER2 model. C) Image of tumors at the end of the experiment in the MMTV-HER2 model. The combinational treatment group showed a trend of decrease in tumor mass, yet the decrease was not significant. D) Tumor mass of threshold method in MMTV-HER2 model. E-F) Tumor growth curve after thresholding in MMTV-HER2 model. Responders showed significantly decreased tumor volumes. H) Tumor growth curve of 4T1 model. I) Image of tumors at the end of the experiment in the 4T1 model. J) Tumor mass of threshold method in the 4T1 model. K-M) Tumor growth curve after thresholding in the 4T1 model. N = 80. R was for responders. NR was for non-responders