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. 2024 Jun 25;26:104. doi: 10.1186/s13058-024-01844-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Intratumoral CD8-specific PET signals, [⁸⁹Zr]Zr-DFO-CD8 SUV_mean, increased in tumors that had an effective response to ICB. A) The mean of standard uptake value (SUV_mean) of responders showed a decreasing trend in the MMTV-HER2 model at day 0. B) From day 0 to 6, changes in SUV_mean of responders showed an increase compared to non-responders in the MMTV-HER2 model. Overall, CD8 + cells were retained/infiltrated from day 0 to day 6 in MMTV-HER2 tumors that responded to ICB. C) Representative images of [⁸⁹Zr]Zr-DFO-CD8 PET from day 0 to day 6 in the combinational treatment group in the MMTV-HER2 model. Yellow circles indicated tumors. All the images are processed at the same setting and decay corrected to the imaging time. D) Day6/day0 intratumoral [⁸⁹Zr]Zr-DFO-CD8 SUV_mean of each treatment group in MMTV-HER2 model. In the combinational treatment group, responders had an increase of [⁸⁹Zr]Zr-DFO-CD8 SUV_mean from day 0 to day 6 compared to non-responders. E) [⁸⁹Zr]Zr-DFO-CD8 SUV_mean at day 0 in 4T1 model. No significance was found. F) The ratio of day6/day0 of [⁸⁹Zr]Zr-DFO-CD8 SUV_mean in 4T1 model. Overall, CD8 + cells were retained/infiltrated from day 0 to day 6 in 4T1 tumors that responded to ICB. G) Representative images of [⁸⁹Zr]Zr-DFO-CD8 PET from day 0 to day 6 in the combinational treatment group in the 4T1 model. Yellow circles indicated tumors. All the images are processed at the same setting and decay corrected to the imaging time. H) Day6/day0 intratumoral [⁸⁹Zr]Zr-DFO-CD8 SUV_mean of each treatment group in the 4T1 model