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. 2024 Jun 20;12(6):1373. doi: 10.3390/biomedicines12061373

Figure 3.

Figure 3

Assessment of hematoma volume and blood–brain barrier integrity post-ICH. The effects of ICH and the therapeutic intervention with miR-195-5p on brain injury. (A) Hemoglobin content measurements, indicative of hematoma volume, reveal that while the ICH and ICH + NC-mimic groups show an increase in the ipsilateral hemisphere suggestive of larger hematomas, miR-195-5p treatment significantly reduces this volume, indicating its potential to alleviate hemorrhage-associated brain damage. (B) The assessment of BBB integrity through Evans blue dye extravasation demonstrates heightened permeability in the ICH groups, which is notably decreased following treatment with miR-195-5p. (** p < 0.01 and *** p < 0. 001 different from control, ### p < 0. 001 compared with ICH + NC-mimic) (n = 4 in each group).