Table 1.

Summary of the studies that applied cell replacement strategies to improve remyelination.

Disease Model	Transplanted Cells	Co-Intervention	Outcomes	Reference
SCI	OPC-committed NPCs	Chondroitinase ABC	Formation of nodes of Ranvier. Improvement in remyelination and motor functions.	[90]
SCI	NPCs	Overexpression of human arginine decarboxylase	Decreased glial scar formation. Increased remyelination and neuronal differentiation. Improvement in neurological outcomes.	[87]
MS (EAE)	NPCs	-	Decreased demyelination and astrogliosis. Increased remyelination and improvement in neurological scores.	[96]
SCI	Pre-OPCs	Glial scar ablation	Generation of new OLs and neurons.	[99]