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Surface markers specific to Trm cells and their functions, and markers that are downregulated are shown. Trm cells play a role in PD-1/CTLA-4-mediated cancer immunity, infection defense, and thereby, immune memory. CD103 and CD49a are associated with E-cadherin and collagen, respectively. Trm cells are characterized by the downregulation of S1PR1, S1PR5, CD62L, CCR7, KLF4, and eomesodermin (EOMES).
