Table 1.
Characteristics of the Study population
| Total (n = 3,229) | |
|---|---|
| Age, y | 56.1 (5.65, 45.8–68.0) |
| Education level, n(%) | |
| < 8 years | 1304 (40.4) |
| 9–12 years | 1212 (37.5) |
| ≥ 13 years | 713 (22.1) |
| Time to follow-up visit, y | 17.4 (1.43, 14.3–20.8) |
| Follow-up AQT | |
| Part 3 (color and form, seconds) | 74.0 (20.2, 35–295) |
| Follow-up MMSE | |
| Total score | 28.1 (1.81, 11–30) |
| Orientation and memory scores | 12.1 (1.02, 4–13) |
| Hypertension | |
| Hypertension, from baseline questionnaire, n (%) | 444 (13.8) |
| Systolic blood pressure (mmHg) | 139 (18.0) |
| Lipid levels | |
| Total cholesterol (mmol/l) | 6.13 (1.07) |
| HDL-C (mmol/l) | 1.41 (0.372) |
| LDL-C (mmol/l) | 4.13 (0.976) |
| Triglycerides (mmol/l) | 1.29 (0.692) |
| Lipid lowering medication, n (%) | 63 (2.0) |
| Diabetes | |
| Diabetes at baseline, n (%) | 179 (5.5) |
| HbA1c (%) | 4.80 (0.598) |
| Fasting glucose (mmol/l) | 5.01 (0.997) |
| Stroke (prevalent or incident), n (%) | 241 (7.5) |
| Body Mass Index a | 25.4 (3.69) |
| Smoking, n(%) | |
| Current smoker | 723 (22.4) |
| Former smoker | 1137 (35.2) |
| Never smoker | 1368 (42.4) |
| Alcohol consumption, g/day | 10.8 (11.6) |
| Q1 (≤ 0.23 standard drinks/day) | 0.61 (0.77) |
| Q2 (0.24–0.56 standard drinks/day) | 5.15 (1.60) |
| Q3 (0.57–1.01 standard drinks/day) | 11.01 (2.09) |
| Q4 (≥ 1.02 standard drinks/day) | 26.33 (12.41) |
| APOE genotype, n (%) | |
| ε2/ε2 or ε2/ε3 | 397 (12.3) |
| ε3/ε3 | 1780 (55.1) |
| ε2/ε4 | 79 (2.4) |
| ε3/ε4 or ε4/ε4 | 812 (25.1) |
| Physical activity (METh/week) b | 3.41 (1.15) |
Data are shown as mean (SD, range) if not otherwise specified. All data represent baseline data except for MMSE and AQT scores at follow-up. Stroke is accounted for as prevalent at baseline or incident during follow-up
a Calculated as weight in kilograms divided by height in meters squared
b Physical activity as metabolic equivalent hours/week (METh/week). One METh is defined as the metabolic intensity when a person is at rest. METh/week was computed by multiplying time (hours) spent on each activity by the respective metabolic equivalent task (intensity) factor (MET).