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. 2024 May 27;8(2):21. doi: 10.3390/epigenomes8020021

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effects of histone variants on nucleosome DNA accessibility assessed with MNase assays. (A) Schematic of the MNase digestion of nucleosomes. (B) Representative acrylamide gels of the MNase digestion of canonical, H3.3, H2A.Z, and H2A.Z-H3.3 double-variant nucleosomes, respectively. The digestion products of different sizes (145–167, 130, 120) are labeled. (C) Quantification of the digestion DNA products shown in (B), representing the fraction of cleaved nucleosome DNA as a function of time. Data are presented as the mean ± SD, n = 3. (D) p-values of the abovementioned quantification analysis, estimated using the two-way ANOVA.