Table 1.
The table shows the percentage of children (with the percentage of males in brackets) for each QTc ≥ cut-off value (listed in the first column). These percentages are based on ECGs taken at regular intervals (ECG 1.0 to ECG 4.0 and ECG 1.1 to ECG 1.4) and Holter ECGs (shown in the last column). To aid interpretation, the color of each box corresponds to the percentage of children (with the percentage of males in brackets) who have a QTc exceeding the specified cut-off and falling within the range indicated in the table legend.
| Included at Follow-Up, QTc (ms) | ECG 1.0, n. (% Males) | ECG 2.0, n. (% Males) | ECG 3.0, n. (% Males) | ECG 4.0, n. (% Males) | ECG 1.1, n. (% Males) | ECG 2.1, n. (% Males) | ECG 3.1, n. (% Males) | ECG 4.1, n. (% Males) | Holter 24 h ECG, n. (% Males) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Infant enrolled | 2245 (39.9) | 667 (35.2) | 254 (29.1) | 52 (25) | 164 (37.8) | 119 (32.8) | 87 (24.1) | 23 (26.1) | 44 (31.8) | |||||
| % (% males) | % (% males) | % (% males) | % (% males) | % (% males) | % (% males) | % (% males) | % (% males) | % (% males) | ||||||
| ≥435 | 98.8 (38.9) | 99.3 (35.2) | 95.7 (58.9) | 55.8 (24.1) | 99.4 (37.4) | 72.6 (32.8) | 100 (24.1) | 100 (26.1) | 100 (30.2) | |||||
| ≥440 | 86.8 (39.8) | 88.0 (34.2) | 89.4 (27.3) | 92.3 (27.1) | 89.0 (37.0) | 64.6 (32.1) | 92.0 (23.8) | 91.3 (28.6) | 95.5 (25.6) | |||||
| ≥445 | 37.8 (37.6) | 46.0 (27.4) | 59.8 (24.3) | 57.7 (13.3) | 53.0 (32.2) | 40.2 (24.2) | 62.1 (22.2) | 60.9 (14.3) | 95.5 (31.0) | |||||
| ≥450 | 33.4 (37.8) | 42.3 (26.2) | 55.9 (25.4) | 53.8 (14.3) | 48.2 (32.9) | 38.4 (25.4) | 58.6 (23.5) | 56.2 (14.4) | 86.4 (23.2) | |||||
| ≥455 | 14.7 (34.5) | 22.8 (22.4) | 26.8 (26.5) | 34.6 (11.1) | 26.8 (29.5) | 26.2 (23.3) | 26.4 (26.1) | 39.1 (11.1) | 68.2 (26.7) | |||||
| ≥460 | 9.6 (30.6) | 13.2 (14.8) | 17.3 (29.5) | 19.2 (20.0) | 20.1 (30.3) | 16.5 (18.4) | 14.9 (30.8) | 21.7 (20) | 59.1 (15.9) | |||||
| ≥465 | 4.9 (33.3) | 8.6 (8.3) | 8.7 (18.2) | 11.5 (33.3) | 12.8 (42.9) | 7.3 (16.7) | 4.6 (0) | 13.0 (33.3) | 45.5 (25.0) | |||||
| ≥470 | 3.6 (34.6) | 5.4 (5.6) | 5.4 (0) | 3.8 (0) | 7.9 (38.5) | 7.3 (16.7) | 4.6 (0) | 4.3 (0) | 29.5 (7.9) | |||||
| ≥475 | 0.67 (26.7) | 2.4 (6.3) | 3.5 (0) | 3.8 (0) | 2.4 (25) | 3.7 (16.7) | 3.4 (0) | 4.3 (0) | 22.7 (20.0) | |||||
| ≥480 | 0.49 (36.4) | 2.4 (6.3) | 3.5 (0) | 3.8 (0) | 1.8 (33.3) | 3.7 (16.7) | 3.4 (0) | 4.3 (0) | 20.5 (5.5) | |||||
| ≥485 | 0.22 (20) | 2.1 (7.1) | 2.0 (0) | - | 0.61 (0) | 3.0 (20) | 1.1 (0) | - | 18.2 (25.0) | |||||
| ≥490 | 0.22 (20) | 1.6 (9.1) | 2.5 (0) | - | 0.61 (0) | 2.4 (25) | 1.1 (0) | - | 15.9 (4.3) | |||||
| ≥495 | 0.22 (0) | 1.3 (0) | 1.2 (0) | - | 0.61 (0) | 1.8 (0) | 1.1 (0) | - | 11.4 (20.0) | |||||
| ≥500 | 0.22 (0) | 1.3 (0) | 1.2 (0) | - | - | - | - | - | 9.1 (2.4) | |||||
| ≥510 | 0.22 (0) | 0.9 (0) | 1.2 (0) | - | - | - | - | - | 4.5 (1.2) | |||||
| From ECG 1.0 to ECG 4.0 | 100–80% | 80–60% | 60–40% | 40–20% | 20–0% | |||||||||
| From ECG 1.1 to ECG 4.1 | 100–80% | 80–60% | 60–40% | 40–20% | 20–0% | |||||||||
| Holter 24 h ECG | 100–80% | 80–60% | 60–40% | 40–20% | 20–0% | |||||||||
Legend: ECG, electrocardiogram.