Table 2.
The table displays the mean QTc values ± SD of infants whose QTc values are greater than or equal to (≥) a predefined cut-off value listed in the first column. The values are presented for consecutive ECGs (from ECG 1.0 to ECG 4.0 and from ECG 1.1 to ECG 4.1). The last column shows the mean QTc values ± SD from a Holter ECG for infants meeting the same criteria (predefined cut-off value in the first column). For improved clarity, the color of each box corresponds to the range of mean QTc values ± SD that fall within 0–20% of the total children included at each consecutive ECG and Holter ECG measurement.
| Included at Follow-Up (QTc, ms) | ECG 1.0, Mean QTc ± SD (Min–Max) ms |
ECG 2.0, Mean QTc ± SD (Min–Max) ms |
ECG 3.0, Mean QTc ± SD (Min–Max) ms |
ECG 4.0, Mean QTc ± SD (Min–Max) ms |
ECG 1.1, Mean QTc ± SD (Min–Max) ms |
ECG 2.1, Mean QTc ± SD (Min–Max) ms |
ECG 3.1, Mean QTc ± SD (Min–Max) ms |
ECG 4.1, Mean QTc ± SD (Min–Max) ms |
Holter 24 h ECG, Mean QTc ± SD (Min–Max) ms |
|---|---|---|---|---|---|---|---|---|---|
| Infant enrolled | 445.9 ± 9.4 (392–513) |
448.1 ± 12.1 (427–513) |
450.2 ± 12.7 (428–520) |
450.5 ± 11.2 (435–482) |
449.6 ± 11.9 (433–513) |
451.7 ± 14.8 (435–513) |
450.4 ± 12.1 (435–520) |
451.3 ± 11.6 (435–482) |
465.7 ± 19.2 (430–511) |
| ≥435 | 446.1 ± 9.2 | 448.3 ± 12.1 | 450.3 ± 12.6 | 449.9 ± 10.9 | 449.7 ± 11.9 | 451.7 ± 14.8 | 450.4 ± 12.1 | 451.3 ± 11.6 | 466.5 ± 18.6 |
| ≥440 | 447.5 ± 9.0 | 449.8 ± 11.9 | 452.0 ± 12.2 | 451.8 ± 10.6 | 451.3 ± 11.5 | 453.6 ± 14.6 | 451.7 ± 11.7 | 452.9 ± 11.0 | 467.1 ± 18.3 |
| ≥445 | 455.2 ± 8.7 | 457.5 ± 12.1 | 457.0 ± 12.0 | 458.0 ± 8.7 | 457.9 ± 10.7 | 460.9 ± 14.1 | 456.3 ± 11.7 | 458.5 ± 9.0 | 467.2 ± 18.3 |
| ≥450 | 456.3 ± 8.6 | 458.4 ± 12.2) | 457.7 ± 12.2 | 458.8 ± 8.5 | 459.0 ± 10.6 | 461.5 ± 14.1 | 456.9 ± 11.8 | 459.4 ± 8.7 | 469.4 ± 17.8 |
| ≥455 | 463.7 ± 8.3 | 465.2 ± 13.3 | 465.6 ± 13.7 | 463.1 ± 7.6 | 465.8 ± 9.8 | 466.7 ± 14.4 | 464.7 ± 14.1 | 463.1 ± 7.8 | 474.1 ± 17.2 |
| ≥460 | 467.0 ± 8.6 | 470.8 ± 15.1 | 470 ± 15.4 | 457.2 ± 8.2 | 468.5 ± 10.0 | 472.5 ± 15.7 | 470.4 ± 16.9 | 467.2 ± 8.7 | 476.9 ± 16.7 |
| ≥465 | 472.6 ± 8.9 | 479.2 ± 16.2 | 479.3 ± 17.4 | 471.3 ± 8.3 | 472.7 ± 10.3 | 484.7 ± 16.5 | 489.5 ± 20.7 | (466–482) | 481.6 ± 16.4 |
| ≥470 | 475.0 ± 9.3 | 483.7 ± 16.4 | 488.5 ± 17.4 | 482 | 476.9 ± 11.3 | 484.7 ± 16.5 | 489.5 ± 20.7 | 482 | 489.9 ± 14.4 |
| ≥475 | 488.4 ± 15.7 | 499.1 ± 13.3 | 495.4 ± 16.7 | 482 | 487.3 ± 17.3 | 497.5 ± 14.2 | (482–520) | 482 | 495.1 ± 12.2 |
| ≥480 | 492.9 ± 16.2 | 499.1 ± 13.3 | 495.4 ± 16.7 | 482 | 513 | 497.5 ± 14.2 | 520 | 482 | 497.3 ± 10.5 |
| ≥485 | 508.4 ± 10.3 | 501 ± 11.8 | 506 ± 15.2 | - | 513 | 501 ± 12.7 | 520 | - | 499.5 ± 8.8 |
| ≥490 | 508.4 ± 10.3 | 506.4 ± 8.6 | 506 ± 15.2 | - | 513 | 505 ± 10.4 | 520 | - | 501.6 ± 7.1 |
| ≥495 | 513 | 510 ± 3.1 | (511–520) | - | 513 | (506–513) | 520 | - | 504.6 ± 5.9 |
| ≥500 | 513 | 510 ± 3.1 | (511–520) | - | - | - | - | - | 506.0 ± 5.8 |
| ≥510 | 513 | 512.0 ± 1.1 | (511–520) | - | - | - | - | - | 511 |
| From ECG 1.0 to ECG 4.0 | 20–0% | ||||||||
| From ECG 1.1 to ECG 4.1 | 20–0% | ||||||||
| Holter 24 h ECG | 20–0% | ||||||||
Legend: ECG, electrocardiogram; SD, standard deviation.