TABLE 1.
Induction of serum Absa
| Mice | Immunization route | Mean anti-NP Ab titerb (log2) | Mean titersb (log2) of neutralizing Ab to influenza virus strain
|
|
|---|---|---|---|---|
| A/Udorn (H3N2) | A/PR/8/34 (H1N1) | |||
| IFN-γ+/+ | No virus | 10.96 | <3 | <3 |
| IFN-γ+/+ | i.v. | 18.52 ± 0.72 | 9.35 ± 0.22 | <5 |
| IFN-γ+/+ | TRT | 19.56 ± 0.54 | 9.30 ± 0.59c | <5 |
| IFN-γ−/− | TRT | 18.16 ± 0.83 | 8.65 ± 0.45d | <5 |
a
IFN-γ−/− and immunocompetent (IFN-γ+/+) BALB/c mice were immunized by i.v. or TRT exposure with 5 × 105 PFU of influenza virus A/Udorn (H3N2) per mouse. Four weeks later, sera were collected and assayed for levels of Abs.
b
The values represent the means of Ab titers for five mice in each group, and (where shown) SEM.
c,d The two-tailed P value is 0.0943, considered not significant.