Table 3.
MRI measurements for PAD patients and matched controls.
| Variables | PAD Patients (n = 18) | Controls (n = 19) | p-Value |
|---|---|---|---|
| Native peak T1 of composite arteries (ms) | 1729 (1679–1810) | 1688 (1637–1756) | 0.17 |
| Cross-sectional area, anterior muscle group (mm2) | 795 (678–980) | 971 (802–1309) | 0.045 |
| Cross-sectional area, lateral muscle group (mm2) | 454 (385–554) | 597 (483–803) | 0.007 |
| Cross-sectional area, deep posterior muscle group (mm2) | 677 (531–803) | 624 (491–947) | 1.00 |
| Cross-sectional area, soleus muscle (mm2) | 1459 (1235–1882) | 1759 (1333–2322) | 0.18 |
| Cross-sectional area, gastrocnemius muscle (mm2) | 1326 (1099–1800) | 1649 (1204–2146) | 0.11 |
| Average cross-sectional area (mm2) | 954 (828–1175) | 1175 (954–1546) | 0.055 |
| Native peak T1, anterior muscle group (ms) | 1835.5 (188) | 1746 (163) | 0.027 |
| Native peak T1, lateral muscle group (ms) | 1907 (65) | 1755 (279) | 0.002 |
| Native peak T1, deep posterior muscle group (ms) | 1917.5 (106) | 1782 (296) | 0.012 |
| Native peak T1, soleus muscle (ms) | 1930 (143) | 1899 (164) | 0.29 |
| Native peak T1, gastrocnemius muscle (ms) | 1945.5 (50) | 1934 (160) | 0.74 |
| Minimum T1, anterior muscle group (ms) | 878 (777–963) | 878 (777–963) | 0.53 |
| Minimum T1, lateral muscle group (ms) | 897 (818–955) | 840 (718–926) | 0.45 |
| Minimum T1, deep posterior muscle group (ms) | 729 (637–802) | 712 (595–889) | 0.87 |
| Minimum T1, soleus muscle (ms) | 728 (643–813) | 823 (797–912) | 0.024 |
| Minimum T1, gastrocnemius muscle (ms) | 730 (524–900) | 651 (0–809) | 0.55 |
| Average cross-sectional native peak T1 (ms) | 1902 (1877–1924) | 1823 (1709–1883) | 0.005 |
| Average cross-sectional mean T1 (ms) | 1218 (1143–1263) | 1190 (1140–1258) | 0.45 |
| ECV, anterior muscle group (%) | 26.4 (21.2–31.5) | 17.3 (10.2–25.1) | 0.046 |
| ECV, lateral muscle group (%) | 21.7 (15.1–31.2) | 24.7 (19.6–38.5) | 0.43 |
| ECV, deep posterior muscle group (%) | 29.0 (22.5–36.1) | 24.1 (16.5–31.0) | 0.19 |
| ECV, soleus muscle (%) | 22.7 (19.5–27.8) | 13.8 (10.2–19.1) | 0.020 |
| ECV, gastrocnemius muscle (%) | 21.8 (15.1–26.5) | 16.8 (13.3–23.6) | 0.38 |
| ECV, averaged over 5 muscle compartments (%) | 22.9 (21.0–27.5) | 24.5 (20.7–28.0) | 0.68 |
Values are reported as median (interquartile range, IQR); PAD: peripheral artery disease; ms: milliseconds; ECV: extracellular volume fraction. Composite denotes the T1 average for the peroneal, posterior tibialis, and anterior tibialis arteries combined. Average cross-sectional: average T1 times over all five muscle groups. ECV in controls (n = 12), ECV in PAD patients (n = 16).