Table 1.
Comparative biophysical data for selective Aβ preparations. Data taken from [9,11,12]. Samples labeled “gang” contain 5 mol% porcine brain total gangliosides. Aβ preparations were either in form of monomers (mon) or fibrils (fib). Average values S.E. (n = 3).
| Samples | ||||
|---|---|---|---|---|
| SM/Chol (mon) | SM/Chol (fib) | SM/Chol/gang (mon) | SM/Chol/gang (fib) | |
|
technique
(parameter) |
||||
| Centrifugation (% bound peptide) |
41 ± 3.3 | - | 84 ± 3.9 | - |
| ITC (Ka, M−1, ×104) | - | 21.0 ± 0.4 | 28.0 ± 2 | 13.0 ± 0.3 |
| ITC (ΔH, kcal/mol) | - | −0.87 ± 0.05 | −108.2 ± 12 | −29.6 ± 0.4 |
| ITC (ΔS, kcal/mol K) | - | 21.6 ± 0.2 | −324 ± 8 | −71.9 ± 1.8 |
| Langmuir balance (max πi, mN/m) |
32 ± 0.5 | 21 ± 0.4 | 34 ± 0.0 | 24 ± 0.4 |