Table 1.
Gene transcript levels in tumor and normal tissue samples from patients with HNSCC.
| EGLN1 | EGLN3 | HIF1A | ||||
|---|---|---|---|---|---|---|
| Mean/Median | p-Value | Mean/Median | p-Value | Mean/Median | p-Value | |
| Age ≤ 60 | tumor = 0.52 normal = 1.05 |
0.001 | tumor = 1.06 normal = 0.47 |
0.014 | tumor = 1.31 normal = 1.09 |
ns |
| Age > 60 | tumor = 0.59 normal = 0.95 |
0.039 | tumor = 1.31 normal = 0.66 |
0.006 | tumor = 1.35 normal = 0.67 |
<0.0001 |
| Male | tumor = 0.57 normal = 0.89 |
ns | tumor = 1.27 normal = 0.62 |
0.004 | tumor = 1.35 normal = 0.69 |
<0.0001 |
| Female | tumor = 0.59 normal = 0.95 |
0.023 | tumor = 0.84 normal = 0.45 |
ns | tumor = 1.35 normal = 1.00 |
ns |
| T1–T2 | tumor = 0.61 normal = 1.23 |
ns | tumor = 0.67 normal = 0.42 |
ns | tumor = 1.34 normal = 0.70 |
0.019 |
| T3 | tumor = 0.50 normal = 0.87 |
ns | tumor = 1.47 normal = 0.69 |
0.002 | tumor = 1.65 normal = 1.24 |
0.024 |
| T4 | tumor = 0.57 normal = 0.93 |
0.018 | tumor = 0.90 normal = 0.62 |
ns | tumor = 1.36 normal = 0.81 |
0.018 |
| N0 | tumor = 0.47 normal = 0.93 |
0.011 | tumor = 1.30 normal = 0.87 |
ns | tumor = 1.11 normal = 0.67 |
0.036 |
| N1 | tumor = 0.72 normal = 1.64 |
0.029 | tumor = 1.33 normal = 0.55 | 0.002 | tumor = 1.90 normal = 0.94 |
0.023 |
| N2 | tumor = 0.60 normal = 0.89 |
ns | tumor = 1.41 normal = 0.62 | 0.018 | tumor = 1.65 normal = 1.09 |
ns |
| G2 | tumor = 0.51 normal = 0.85 |
0.037 | tumor = 1.08 normal = 0.66 | 0.039 | tumor = 1.35 normal = 0.81 | 0.0003 |
| G3 | tumor = 0.68 normal = 1.78 |
0.042 | tumor = 1.78 normal = 0.48 |
ns | tumor = 1.64 normal = 1.04 |
ns |
| Oral cavity | tumor = 0.57 normal = 0.95 |
0.032 | tumor = 1.20 normal = 0.54 | < 0.0001 | tumor = 1.50 normal = 0.87 | 0.001 |
Gene transcript levels were measured in triplicate and standardized by PBGD and SDHA reference genes, relative gene expression was calculated using the Pfaffl method. We performed the Mann–Whitney U-test or unpaired t-test based on the normality data distribution. ns—nonsignificant.