Table 1.
The model setup for induction of rheumatoid arthritis, treatment, and blood sampling.
| Study group | RA induction | Treatment | ||||
|---|---|---|---|---|---|---|
|
|
|
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| CFA-Collagen II treatment | No of dose/dose interval | Sampling | NPs and curcumin treatment | No of dose/dose interval | Blood sampling | |
| Normal control | Untreated | 0 | 21st day of experiment | Untreated | 0 | 42nd day of experiment |
| RA control | 250 μl/kg bw | 3/7 days | 7 days after last dose | Untreated | 0 | 21 days after RA induction |
| ZnO NPs treated | 250 μl/kg bw | 3/7 days | 7 days after last dose | 1 ml/kg bw | 3/7 days | 7 days after last dose |
| Curcumin treated | 250 μl/kg bw | 3/7 days | 7 days after last dose | 1 ml/kg bw | 3/7 days | 7 days after last dose |
| ZnO NPs-DC treated | 250 μl/kg bw | 3/7 days | 7 days after last dose | 1 ml/kg bw | 3/7 days | 7 days after last dose |
*
bw: body weight, CFA: Complete Freunds adjuvant, RA: Rheumatoid arthritis, ZnONPs:Zinc oxide nanoparticles, ZnONPs-DC: Zinc oxide nanoparticles doped curcumin.