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. 2024 Jun 14;25(12):6577. doi: 10.3390/ijms25126577

Figure 1.

Figure 1

(A) Mechanical pain and (B) thermal pain were tested via the von Frey test and plantar test, respectively. Wild-type mice, wild-type mice with VBC lesions, and P2X7 KO mice with VBC lesions were respectively defined as the control, CPSP, and P2X7/CPSP groups (n = 8 per group). (C) NeuN expression numbers (D) GFAP expression numbers (E) IBA1 expression numbers in the medial thalamus for the control, CPSP, and P2X7/CPSP groups after behavioral tests. (F) In the qualitative analysis, immunofluorescence staining was performed for the expression of NeuN, GFAP, and IBA1 in the control, CPSP, and P2X7/CPSP groups. Note, gm: the threshold stimulus intensity; %: pain withdrawal latency time on test day/pain withdrawal latency time on baseline day (Day 0); Expression numbers: averaged targeting proteins numbers for each brain slice. P2X7/CPSP: P2X7 receptor knock-out mice that induced the CPSP symptoms. n.s.: nonsignificant differences. * p < 0.05 indicates significant differences.