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. 2024 Jun 14;25(12):6577. doi: 10.3390/ijms25126577

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) MD electrophysiological recording with 1-, 2-, 5-, 10-, and 20-fold nociceptive responses after repeated noxious electric stimuli on the sciatic nerve in the control, CPSP, and P2X7/CPSP groups (n = 6 per group). Electrophysiological data of multiunit numbers in MD with 1- to 20-fold basic electric stimulations on the sciatic nerve in the control, CPSP, and P2X7/CPSP groups for (B) fast component and (C) late component. MD: mediodorsal nucleus of the thalamus. P2X7/CPSP: P2X7 receptor knock-out mice that induced the CPSP symptoms.