Table 1.

The P2X7 hypothesis of CPSP summarizing the results of the CPSP and P2X7 receptor KO groups regarding mechanical and thermal pain, molecular assessments, electrophysiological recordings in the ACC and MD, and P2X4 receptor labeling.

	Previous CPSP Data	Previous P2X7/CPSP Data	CPSP	P2X7/CPSP
Pain behavior
Von Frey test (mechanical)	↑ [2,3,4]	↓ [5]	↑	↓
Plantar test (thermal)	↑ [23]	↓ [5]	↑	↓
Molecular assessments
NeuN (neuron)	↓ [10]	−−	↓	−−
GFAP (astrocyte)	↑ [10,11]	−−	↑	↓
IBA1 (microglia)	↑ [10]	−−	↑	↓
BDNF	i.c. [14,15]	−−	↑	↓
TrkB	↑ [14]	−−	n.s.	n.s.
KCC2	↓ [15]	−−	↓	n.s.
NKCC1	i.c. [15,18,21]	−−	n.s.	n.s.
GABAa	i.c. [15,18,21]	−−	n.s.	n.s.
EEG: ACC recording
CSD amplitude	↑ [26]	↓ [26]	↓	↑
CSD peak latency	−−	−−	n.s.	n.s.
EEG: MD recording for unit numbers
Fast component	↑ [16,17]	↓ [16,17]	↑	↓
Late component	−−	−−	n.s.	n.s.
Muscimol applications
Multiunit	−−	−−	↑	↓
F(CS)%: [Cl−] inside neurons	−−	−−	↑	↓
P2X4 expression		−−
50 kb	−−	−−	n.s.	↑
100 kb	−−	−−	↑	↓

Note: CPSP: central post-stroke pain; ACC: anterior cingulate cortex; MD: medial dorsal nucleus of the thalamus; n.s.: nonsignificant difference; ↑: significant increase; ↓: significant decrease; the CPSP group was compared to the control group; the P2X7/CPSP group was compared to the CPSP group.