Table 4.

Clinimetric indices of SLE activity during pregnancy.

Clinimetric Index	Difference from the Original Version	Assessment Time	Final Score	Flare Definition
LAI-P	Excluded: PGA, fatigue Added: fever, vasculitis, myositis CVA or TP: not scored in aPL+ pt Proteinuria: >500 mg/day or doubling if previous LN, with ↓ C’ o ↑ anti-dsDNA; rule out PE	2 weeks	0–2.6	Increase of 0.25 from the last evaluation
SLEPDAI	Rule out: PE, HELLP, E, infection, Bell’s palsy, placental problems, pregnancy TP Considered physiological factors during pregnancy: ↑ C’, bland knee effusions, ↑ lymphocytes, palmar erythema, hyperventilation due to progesterone and dyspnea due to enlarging uterus, postpartum alopecia	10 days	0–105	4–11: moderate activity; > 12: severe activity
m-SLAM	Excluded: weight loss, ESR, scale for miscellaneous disease manifestations Rule out: PE, E, FM, placental problems, chloasma Considered physiological factors during pregnancy: bland knee effusions, ↑ lymphocytes, palmar erythema, hemodilution, ↓ serum creatinine, hyperventilation due to progesterone, dyspnea due to enlarging uterus, postpartum alopecia	1 months	0-81	≥7: active disease
m-ECLAM	Proteinuria pathological if >500 mg/day after excluding PE Non-hemolytic anemia not considered ESR not considered	1–3 months	0–17.5	≥2: active disease
BILAG2004-P	Rule out: bland knee effusion, peripheral edema of pregnancy and mechanical pain, PE, E, HELLP, APS, melasma, chloasma Physiological during pregnancy: ↑ lymphocytes and neutrophils, ↓ serum creatinine, hemodilution, postpartum alopecia For DD LN-PE: added C’ levels and anti-dsDNA added; excluded hypertension	4 weeks	A–E	A: severe; B: moderate; C: mild stable disease; D: no disease activity; E: no current or previous disease activity

Legend: ↑: increase; ↓: reduction; aPL: antiphospholipid antibody; APS: antiphospholipid syndrome; C’: complement; CVA: cardiovascular accident; DD: differential diagnosis; E: eclampsia; ESR: erythrocyte sedimentation rate; FM: fibromyalgia; HELLP: hemolysis, elevated liver enzymes, and low platelets; LN: lupus nephritis; PE: preeclampsia; PGA: physician global assessment; Pt: patient; TP: thrombocytopenia.