Table 5.
Biomarker | Lupus Nephirtis | Preeclampsia |
---|---|---|
Blood pressure | Normal or ↑ | ↑↑ |
Onset | At any time | >20th GW |
Renal biopsy | May show signs of active nephritis | - |
Serologic markers | ↑ Anti-dsDNA antibodies ↓ Complement levels Normal uric acid Normal or ↓ PLTs |
Not specific, may include ↑ Liver enzymes ↑ Uric acid ↓ PLTs |
Urine analysis | Proteinuria ↑ Active sediment |
Proteinuria ↑↑↑ Not active sediment |
SLE or renal symptoms | Could be present and increasing | Stable |
Angiogenic factors | ↓ (e.g., angiopoietin-2) | ↑ (e.g., soluble fms-like tyrosine kinase-1) |
Anti-angiogenic factors | ↑ (e.g., soluble endoglin) | - |
Legend: ↑: increase; ↓: reduction, GW: gestational week; PLTs: platelets.