Table 2.

Studies describing the effectiveness of different doses of fenfluramine in reducing seizures compared to placebo.

Author of the Study	Year of Publication	Number of Patients	Age of Patients	Dose	% of Seizure Reduction Compared to Placebo	Adverse Effects	Type of Epilepsy
Nabbout et al. [31]	2020	87	6–19	0.4 mg/kg/d	54%	decreased appetite, fever, fatigue, diarrhea	Dravet syndrome
Lagae et al. [32]	2019	119	2–18	0.2 mg/kg/d	42.30%	decreased appetite, fever, fatigue, diarrhea	Dravet syndrome
				0.7 mg/kg/d	74.90%
Specchio N et al. [33]	2020	52	4–14	0.2–0.7 mg/kg/d	77.40%	decreased appetite	Dravet syndrome
Knupp et al. [36]	2023	168	2–18	0.2–0.7 mg/kg/d	25.60%	decreased appetite, fatigue	Dravet syndrome